2-Nitrobenzenesulfonyl chloride → HCID 86690021, compound

HRID 1186747Notes

Reaction equation

HRID 1186747 reaction equation
Cl.[NH2:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:18]3[CH:17]=[CH:16][C:15]4[CH:19]=[CH:20][CH:21]=[CH:22][C:14]=4[C:13]=3[NH:12][C:11](=[O:23])[C:10]2=[O:24])=[CH:5][CH:4]=1.[N+:25]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[S:34](Cl)(=[O:36])=[O:35])([O-:27])=[O:26]>>[O:23]=[C:11]1[NH:12][C:13]2[C:14]3[CH:22]=[CH:21][CH:20]=[CH:19][C:15]=3[CH:16]=[CH:17][C:18]=2[N:9]([C:6]2[CH:7]=[CH:8][C:3]([NH:2][S:34]([C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=3[N+:25]([O-:27])=[O:26])(=[O:35])=[O:36])=[CH:4][CH:5]=2)[C:10]1=[O:24]

Participants

3

Reactant 2

HCID 155402-Nitrobenzenesulfonyl chlorideHCID 86690022HCID 86690022, compound

Product 1

HCID 86690021HCID 86690021, compoundYield 46%

Procedure

4-(4-Aminophenyl)-1,4-dihydrobenzo[f]quinoxaline-2,3-dione hydrochloride (80 mg, 0.24 mmol) and 2-nitrobenzenesulfonyl chloride (78 mg, 0.35 mmol) were used in a process similar to Example 9 to give the titled compound (53 mg, yield 46%) as a white solid.

Sources & evidence

ORD record
ord-8573ca3aab0e47ebadd5e10dfdecc288
Source dataset
uspto-grants-2014_03
Patent number
US08673915B2

Reaction notes

Loading…