Oxalyl chloride → HCID 56640444, compound

HRID 1186749Notes

Reaction equation

HRID 1186749 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[NH:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[O:20][C:21]([CH3:24])=[N:22][N:23]=2)=[CH:15][CH:14]=1.[C:25](Cl)(=[O:29])[C:26](Cl)=[O:27]>>[CH3:24][C:21]1[O:20][C:19]([C:16]2[CH:15]=[CH:14][C:13]([N:12]3[C:3]4[CH:4]=[CH:5][C:6]5[CH:7]=[CH:8][CH:9]=[CH:10][C:11]=5[C:2]=4[NH:1][C:26](=[O:27])[C:25]3=[O:29])=[CH:18][CH:17]=2)=[N:23][N:22]=1

Participants

3

Reactant 2

HCID 65578Oxalyl chlorideHCID 86690024HCID 86690024, compound

Product 1

HCID 56640444HCID 56640444, compoundYield 68%

Procedure

1-Amino-2-[4-(5-methyl-[1,3,4]oxadiazol-2-yl)phenyl]aminonaphthalene (190 mg, 0.6 mmol) and oxalyl chloride were used in a process similar to Example 1(3) to give the titled compound (150 mg, yield 68%) as a gray crystal.

Sources & evidence

ORD record
ord-28f27f25fa694833ae6990e22f4b2194
Source dataset
uspto-grants-2014_03
Patent number
US08673915B2

Reaction notes

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