HRID1186786

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID53256684

未命名化合物

结构：O=C(O)C(F)(F)F.O=C(c1ccccc1C(F)(F)F)N1CC2=C(CNC2)C1

HCID86661599

未命名化合物

PRODUCTS

生成物

结构：O=C(O)C(F)(F)F.O=C(c1ccccc1C(F)(F)F)N1CC2=C(C1)CN(c1ccc(OCC3CCOCC3)nn1)C2

HCID86661601

未命名化合物

PROCEDURE

实验过程

(3,4,5,6-Tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl)(2-trifluoromethylphenyl)methanone trifluoroacetate (example 1b) (500 mg, 1.26 mmol) was reacted analogously to example 4b with 3-chloro-6-(tetrahydropyran-4-ylmethoxy)pyridazine (288.6 mg, 1.26 mmol). Yield: 129 mg (17%), M+H+: 475.18.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b0ce27371b3943c1b22ece9895ef656c
来源数据集: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08673917B2
来源说明: uspto-grants-2014_03

反应 SMILES

[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH2:8]1[C:12]2[CH2:13][NH:14][CH2:15][C:11]=2[CH2:10][N:9]1[C:16]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[C:24]([F:27])([F:26])[F:25])=[O:17].Cl[C:29]1[N:30]=[N:31][C:32]([O:35][CH2:36][CH:37]2[CH2:42][CH2:41][O:40][CH2:39][CH2:38]2)=[CH:33][CH:34]=1>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[O:40]1[CH2:41][CH2:42][CH:37]([CH2:36][O:35][C:32]2[N:31]=[N:30][C:29]([N:14]3[CH2:13][C:12]4[CH2:8][N:9]([C:16]([C:18]5[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=5[C:24]([F:27])([F:25])[F:26])=[O:17])[CH2:10][C:11]=4[CH2:15]3)=[CH:34][CH:33]=2)[CH2:38][CH2:39]1