HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-6-(tetrahydro-2H-pyran-4-ylmethoxy)pyridazine → {5-[6-(Tetrahydropyran-4-ylmethoxy)pyridazin-3-yl]-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl}-(2-trifluoromethylphenyl)methanone trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-6-(tetrahydro-2H-pyran-4-ylmethoxy)pyridazine | HCID 53256684 | — |
| Reactant | (3,4,5,6-Tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl)(2-trifluoromethylphenyl)methanone trifluoroacetate | HCID 86661599 | — |
| Product | {5-[6-(Tetrahydropyran-4-ylmethoxy)pyridazin-3-yl]-3,4,5,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl}-(2-trifluoromethylphenyl)methanone trifluoroacetate | HCID 86661601 | — |
Reaction Steps
(3,4,5,6-Tetrahydro-1H-pyrrolo[3,4-c]pyrrol-2-yl)(2-trifluoromethylphenyl)methanone trifluoroacetate (example 1b) (500 mg, 1.26 mmol) was reacted analogously to example 4b with 3-chloro-6-(tetrahydropyran-4-ylmethoxy)pyridazine (288.6 mg, 1.26 mmol). Yield: 129 mg (17%), M+H+: 475.18.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08673917B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-b0ce27371b3943c1b22ece9895ef656c |
| Source note | uspto-grants-2014_03 |