反应详情

LiBH4 (0.55 mL, 1.1 mmol, 2 M in THF) was added to a stirred solution of ethyl 2-(4-cyano-3-methoxyphenyl)propanoate (0.17 g, 0.73 mmol) in THF (25 mL) at 0° C. The resulting solution was stirred for 12 h. Water (15 mL) was added, and the resulting solution was extracted with dichloromethane (2×50 mL). The combined organic layers were dried over MgSO4, filtered, and evaporated under reduced pressure. The residue was purified by column chromatography eluting with EtOAc-Hexanes (7:3→1:1) to give 4-(1-hydroxypropan-2-yl)-2-methoxybenzonitrile.

1. extractionthe resulting solution was extracted with dichloromethane (2×50 mL)
2. dry with materialThe combined organic layers were dried over MgSO4
3. filtrationfiltered
4. customevaporated under reduced pressure
5. customThe residue was purified by column chromatography
6. washeluting with EtOAc-Hexanes (7:3→1:1)