Piperazine → HCID 49802225, compound

HRID 1187157Notes

Reaction equation

[F:1][C:2]1[C:7]2[C:8](=[O:11])[O:9][CH2:10][C:6]=2[C:5]([CH3:12])=[C:4]([CH:13]2[CH2:15][O:14]2)[CH:3]=1.[NH:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>>[N:16]1([CH2:15][CH:13]([C:4]2[CH:3]=[C:2]([F:1])[C:7]3[C:8](=[O:11])[O:9][CH2:10][C:6]=3[C:5]=2[CH3:12])[OH:14])[CH2:21][CH2:20][N:19]([CH2:15][CH:13]([C:4]2[CH:3]=[C:2]([F:1])[C:7]3[C:8](=[O:11])[O:9][CH2:10][C:6]=3[C:5]=2[CH3:12])[OH:14])[CH2:18][CH2:17]1

Participants

Reactant 2

HCID 4837Piperazine

HCID 59568716HCID 59568716, compound

Product 1

HCID 49802225HCID 49802225, compound

Procedure

5,5′-[piperazine-1,4-diylbis(1-hydroxyethane-2,1-diyl)]bis(7-fluoro-4-methyl-2-benzofuran-1(3H)-one) was prepared in a similar fashion to that described for the synthesis of EXAMPLE 2 starting from 7-Fluoro-4-methyl-5-oxiran-2-yl-2-benzofuran-1(3H)-one and piperazine.

Sources & evidence

ORD record: ord-c78ea6542d504329b78ac0d0a72059e2
Source dataset: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08673920B2

Reaction notes

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