5-(2-Piperazin-1-ylethyl)-2,1,3-benzoxadiazole → 5-(2-{4-[2-(2,1,3-benzoxadiazol-5-yl)ethyl]piperazin-1-yl}-1-hydroxyethyl)-2-benzofuran-1(3H)-one

HRID 1187159Notes

Reaction equation

HRID 1187159 reaction equation
[N:1]1([CH2:7][CH2:8][C:9]2[CH:17]=[CH:16][C:12]3=[N:13][O:14][N:15]=[C:11]3[CH:10]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[O:18]1[CH2:20][CH:19]1[C:21]1[CH:30]=[CH:29][C:24]2[C:25](=[O:28])[O:26][CH2:27][C:23]=2[CH:22]=1>>[N:13]1[O:14][N:15]=[C:11]2[CH:10]=[C:9]([CH2:8][CH2:7][N:1]3[CH2:6][CH2:5][N:4]([CH2:20][CH:19]([C:21]4[CH:30]=[CH:29][C:24]5[C:25](=[O:28])[O:26][CH2:27][C:23]=5[CH:22]=4)[OH:18])[CH2:3][CH2:2]3)[CH:17]=[CH:16][C:12]=12

Participants

3

Reactant 2

HCID 151663825-(2-Piperazin-1-ylethyl)-2,1,3-benzoxadiazoleHCID 595687155-(oxiran-2-yl)-2-benzofuran-1(3H)-one

Product 1

HCID 498024955-(2-{4-[2-(2,1,3-benzoxadiazol-5-yl)ethyl]piperazin-1-yl}-1-hydroxyethyl)-2-benzofuran-1(3H)-one

Procedure

5-(2-{4-[2-(2,1,3-benzoxadiazol-5-yl)ethyl]piperazin-1-yl}-1-hydroxyethyl)-2-benzofuran-1(3H)-one was prepared in a similar fashion as to the synthesis described in EXAMPLE 12 starting from 5-[2-(piperazin-1-yl)ethyl]-2,1,3-benzoxadiazole and 5-oxiran-2-yl-2-benzofuran-1(3H)-one. LC/MS: [(M+1)]+=409.

Sources & evidence

ORD record
ord-2d27af843f2b47f3816e96fed95acc79
Source dataset
uspto-grants-2014_03
Patent number
US08673920B2

Reaction notes

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