反应详情

The compound obtained in Example 74-2 (1.0526 g) was dissolved in methanol (10 ml), and 1 N aqueous solution of sodium hydroxide (10 ml) and THF (10 ml) were added. The mixture was stirred for 2.5 hours. Part of the solvent was removed by distillation while adding water to the reaction solution. After adjusting the pH to 6, the water layer was extracted with chloroform. The extract was dried over anhydrous magnesium sulfate, the solvent was removed by distillation, and the residue was dried under vacuum to obtain the title compound (0.8551 g) as a pale yellow solid.

1. customPart of the solvent was removed by distillation
2. additionwhile adding water to the reaction solution
3. extractionthe water layer was extracted with chloroform
4. dry with materialThe extract was dried over anhydrous magnesium sulfate
5. customthe solvent was removed by distillation
6. customthe residue was dried under vacuum