Isopropanol → HCID 24962071, compound

HRID 1187263Notes

Reaction equation

C([NH:4][C:5]1[N:14]=[C:13](C2N=CNN=2)[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)[CH:11]=2)[N:6]=1)(=O)C.[CH:27]([OH:30])([CH3:29])[CH3:28]>>[NH2:4][C:5]1[N:14]=[C:13]([O:30][CH:27]([CH3:29])[CH3:28])[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:20]3[CH:21]=[CH:22][C:23]([F:26])=[CH:24][CH:25]=3)[CH:11]=2)[N:6]=1

Participants

Reactant 2

HCID 3776Isopropanol

HCID 178474428HCID 178474428, compound

Product 1

HCID 24962071HCID 24962071, compoundYield 85%

Procedure

This compound, synthesized from 2-acetamido-6-(4-fluorophenyl)-4-(1,2,4-triazolyl)-quinazoline and isopropanol in 85% yield using the same procedure as in example 18, was characterized by its mass spectrum as follows: MS (m/z): 283 ([M+H]+, 100).

Sources & evidence

ORD record: ord-eee6d910c6484c93915df96f1f6ce187
Source dataset: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08673929B2

Reaction notes

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