Sodium Carbonate → HCID 59830698, compound

HRID 1187360Notes

Reaction equation

HRID 1187360 reaction equation
C(=O)([O-])[O-].[Na+].[Na+].[CH:7]12[CH2:16][CH:11]3[CH2:12][CH:13]([CH2:15][CH:9]([CH2:10]3)[CH:8]1[NH:17][C:18]([C:20]1[C:21](Cl)=[N:22][C:23]([Cl:26])=[CH:24][CH:25]=1)=[O:19])[CH2:14]2.[CH:28]1([SH:33])[CH2:32][CH2:31][CH2:30][CH2:29]1>CN(C=O)C>[CH:9]12[CH2:15][CH:13]3[CH2:12][CH:11]([CH2:16][CH:7]([CH2:14]3)[CH:8]1[NH:17][C:18]([C:20]1[C:21]([S:33][CH:28]3[CH2:32][CH2:31][CH2:30][CH2:29]3)=[N:22][C:23]([Cl:26])=[CH:24][CH:25]=1)=[O:19])[CH2:10]2

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 15510CyclopentanethiolHCID 59830729HCID 59830729, compound

Product 1

HCID 59830698HCID 59830698, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
60 °C

Procedure

Anhydrous Sodium carbonate (2.201 mL, 52.58 mmol) was added in one portion to N-(2-adamantyl)-2,6-dichloro-pyridine-3-carboxamide (5.7 g, 17.53 mmol) and cyclopentyl mercaptan (1.885 mL, 17.53 mmol) in DMF (50 mL) under nitrogen. The resulting suspension was stirred at 60° C. for 6 hours.

Sources & evidence

ORD record
ord-68a9a0e1851043838e79d5493b67aeb2
Source dataset
uspto-grants-2014_03
Patent number
US08673938B2

Reaction notes

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