反应详情

The compound obtained in Example 90-2 (14.2 mg) was dissolved in methanol (0.3 ml), and 4 mol/l hydrochloric acid/dioxane solution (0.3 ml) was added to the solution. After the reaction for 3.5 hours, the reaction solution was concentrated. The residue obtained was purified by silica gel column chromatography (0.5 g, chloroform/methanol/water=7/3/0.5) and treated with hydrochloric acid to obtain hydrochloride of the title compound (8.1 mg) as a white solid.

1. customAfter the reaction for 3.5 hours
2. concentrationthe reaction solution was concentrated
3. customThe residue obtained
4. customwas purified by silica gel column chromatography (0.5 g, chloroform/methanol/water=7/3/0.5)
5. additiontreated with hydrochloric acid