Trifluoroacetic acid → HCID 67006949, compound

HRID 1187757Notes

Reaction equation

HRID 1187757 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([NH:10][C:11]2[N:16]=[C:15]([N:17]3[CH2:20][CH:19]([CH2:21][NH:22]C(=O)OC(C)(C)C)[CH2:18]3)[CH:14]=[C:13]([NH:30][C:31]3[CH:36]=[N:35][CH:34]=[CH:33][N:32]=3)[N:12]=2)[CH3:9])=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>ClCCl>[NH2:22][CH2:21][CH:19]1[CH2:18][N:17]([C:15]2[N:16]=[C:11]([NH:10][C@H:8]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)[CH3:9])[N:12]=[C:13]([NH:30][C:31]3[CH:36]=[N:35][CH:34]=[CH:33][N:32]=3)[CH:14]=2)[CH2:20]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 70672081HCID 70672081, compound

Product 1

HCID 67006949HCID 67006949, compoundYield 98.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

80 mg of t-butyl (S)-(1-{2-[1-(4-fluorophenyl)ethylamino]-6-(pyrazin-2-ylamino)pyrimidin-4-yl}azetidin-3-yl)methylcarbamate was dissolved in 4 ml of dichloromethane, and 0.8 ml of trifluoroacetic acid was added thereto, and the mixture solution was stirred at room temperature for 1 hour. The solvent was distilled off under reduced pressure, and then the obtained residue was purified by silica gel column chromatography to obtain 63 mg of the objective compound as a brown amorphous solid.

Workup

  1. distillationThe solvent was distilled off under reduced pressure
  2. customthe obtained residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-065993a8b0c34a70b58546df56d5e5e0
Source dataset
uspto-grants-2014_03
Patent number
US08673891B2

Reaction notes

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