N,N-dicyclopropyl-6-ethyl-1-methyl-4-thioureido-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide → N,N-dicyclopropyl-6-ethyl-4-(4-(isopropylsulfonylmethyl)thiazol-2-ylamino)-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide

HRID 1188034Notes

Reaction equation

HRID 1188034 reaction equation
[CH:1]1([N:4]([CH:26]2[CH2:28][CH2:27]2)[C:5]([C:7]2[N:23]([CH2:24][CH3:25])[C:10]3=[N:11][C:12]([NH:19][C:20]([NH2:22])=[S:21])=[C:13]4[N:17]=[CH:16][N:15]([CH3:18])[C:14]4=[C:9]3[CH:8]=2)=[O:6])[CH2:3][CH2:2]1.Cl[CH:30]([S:34]([CH:37]([CH3:39])[CH3:38])(=[O:36])=[O:35])[C:31](=O)[CH3:32]>>[CH:26]1([N:4]([CH:1]2[CH2:2][CH2:3]2)[C:5]([C:7]2[N:23]([CH2:24][CH3:25])[C:10]3=[N:11][C:12]([NH:19][C:20]4[S:21][CH:32]=[C:31]([CH2:30][S:34]([CH:37]([CH3:39])[CH3:38])(=[O:36])=[O:35])[N:22]=4)=[C:13]4[N:17]=[CH:16][N:15]([CH3:18])[C:14]4=[C:9]3[CH:8]=2)=[O:6])[CH2:27][CH2:28]1

Participants

3

Reactant 2

HCID 58180527N,N-dicyclopropyl-6-ethyl-1-methyl-4-thioureido-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamideHCID 581806351-Chloro-1-(isopropylsulfonyl)propan-2-one

Product 1

HCID 58180569N,N-dicyclopropyl-6-ethyl-4-(4-(isopropylsulfonylmethyl)thiazol-2-ylamino)-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide

Procedure

Prepared from N,N-dicyclopropyl-6-ethyl-1-methyl-4-thioureido-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide (example 2B) and 1-chloro-1-(isopropylsulfonyl)propan-2-one (example 5a) using same procedure as reported for 2.

Sources & evidence

ORD record
ord-f7a8ee4b92c84350a073637178b56cde
Source dataset
uspto-grants-2014_03
Patent number
US08673933B2

Reaction notes

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