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HRID1188139

反应详情

EQUATION

反应方程式

HRID 1188139 的结构方程式

REACTANTS

反应物

1
结构：Cc1ccc(-c2csc(NC(=O)c3cnc(NC(=O)c4cnc(Br)s4)s3)n2)cc1
HCID59408753

未命名化合物

PRODUCTS

生成物

1
结构：CCCNc1ncc(C(=O)Nc2ncc(C(=O)Nc3nc(-c4ccc(C)cc4)cs3)s2)s1
HCID86643476

未命名化合物

收率 206.3%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCCN
溶剂HCID7852

Propylamine

C3H9N

PROCEDURE

实验过程

A solution of 2-bromo-N-(5-(4-p-tolylthiazol-2-ylcarbamoyl)thiazol-2-yl)thiazole-5-carboxamide (15 mg, 0.03 mmol) in neat propylamine (0.5 mL) was stirred at reflux for 24 hrs. The solvent was evaporated and the crude product was purified by column chromatography (0%-5% MeOH/AcOEt) yielding 2-(propylamino)-N-(5-(4-p-tolylthiazol-2-ylcarbamoyl)-thiazol-2-yl)thiazole-5-carboxamide (15 mg, 17%).

WORKUP

后处理

  1. temperatureat reflux for 24 hrs
  2. customThe solvent was evaporated
  3. customthe crude product was purified by column chromatography (0%-5% MeOH/AcOEt)