Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Iodoethane → 3-(3-Chloro-4-fluorophenyl)-1-ethyl-3-methoxypyrrolidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Iodoethane | HCID 6340 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 3-(3-Chloro-4-fluorophenyl)-3-methoxypyrrolidine | HCID 46219356 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-(3-Chloro-4-fluorophenyl)-1-ethyl-3-methoxypyrrolidine | HCID 46219358 | — |
반응 단계
Preparation according to Example 22. (+)-3-(3-chloro-4-fluorophenyl)-3-methoxypyrrolidine (0.01 g, 0.043 mmol), triethylamine (12.1 μL, 0.086 mmol), tetrahydrofuran (2 ml) and iodoethane (5.2 μL, 0.065 mmol). The crude product analyzed by GCMS. Analysis showed 83% conversion. MS m/z (relative intensity, 70 eV) 257 (M+, 6), 242 (48), 227 (27), 157 (38), 71 (bp).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08673962B2 |
| 출처 데이터셋 | uspto-grants-2014_03 |
| ORD ID | ord-159ac5ef3653414895a8af920f9fb688 |
| 출처 메모 | uspto-grants-2014_03 |