Iodoethane → 3-(3-Chloro-4-fluorophenyl)-1-ethyl-3-methoxypyrrolidine

HRID 1188181노트

반응식

HRID 1188181 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([O:14][CH3:15])[CH2:13][CH2:12][NH:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[F:8].[CH2:16](N(CC)CC)[CH3:17].ICC>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([O:14][CH3:15])[CH2:13][CH2:12][N:11]([CH2:16][CH3:17])[CH2:10]2)[CH:5]=[CH:6][C:7]=1[F:8]

참가 물질

5

반응물 3

HCID 6340IodoethaneHCID 8471TriethylamineHCID 462193563-(3-Chloro-4-fluorophenyl)-3-methoxypyrrolidine

생성물 1

HCID 462193583-(3-Chloro-4-fluorophenyl)-1-ethyl-3-methoxypyrrolidine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Preparation according to Example 22. (+)-3-(3-chloro-4-fluorophenyl)-3-methoxypyrrolidine (0.01 g, 0.043 mmol), triethylamine (12.1 μL, 0.086 mmol), tetrahydrofuran (2 ml) and iodoethane (5.2 μL, 0.065 mmol). The crude product analyzed by GCMS. Analysis showed 83% conversion. MS m/z (relative intensity, 70 eV) 257 (M+, 6), 242 (48), 227 (27), 157 (38), 71 (bp).

후처리

  1. customPreparation

출처 및 근거

ORD 기록
ord-159ac5ef3653414895a8af920f9fb688
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08673962B2

반응 노트

불러오는 중…