HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1188296Generated: October 26, 2026
Piperazine → 2-Methyl-1-(4-methylsulfanylphenyl)-2-piperazin-1-yl-propan-1-one
https://huagongshe.com/reaction/1188296
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 2-Methoxy-3,3-dimethyl-2-(4-methylsulfanylphenyl)oxirane | HCID 20192525 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Methyl-1-(4-methylsulfanylphenyl)-2-piperazin-1-yl-propan-1-one | HCID 23325725 | — |
Reaction Steps
Further, in a 500 mL four-neck flask provided with a stirrer, a condenser, and a thermocouple, the compound (c) and 31 g of piperazine were added, followed by stirring at 130° C. for 6 hours. After cooling, 80 mL of dichloromethane was added, and an organic layer was washed three times with 70 mL of water. The organic layer was dried with anhydrous sodium sulfate and concentrated to produce 60.7 g of 2-methyl-1-(4-methylsulfanylphenyl)-2-piperazin-1-yl-propan-1-one (12).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08674089B2 |
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| Source dataset | uspto-grants-2014_03 |
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| ORD ID | ord-924c4bc3a53c456787de4b2d41573fe2 |
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| Source note | uspto-grants-2014_03 |
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