Bromomethylcyclopropane → HCID 57800323, compound

HRID 1188423Notes

Reaction equation

HRID 1188423 reaction equation
[Br:1][C:2]1[C:3]([C:12]([F:15])([F:14])[F:13])=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([CH3:11])=[CH:5]2.Br[CH2:17][CH:18]1[CH2:20][CH2:19]1>>[Br:1][C:2]1[C:3]([C:12]([F:13])([F:15])[F:14])=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:17][CH:18]1[CH2:20][CH2:19]1)[C:6]([CH3:11])=[CH:5]2

Participants

3

Reactant 2

HCID 81503BromomethylcyclopropaneHCID 578001615-bromo-2-methyl-4-(trifluoromethyl)-1H-indole

Product 1

HCID 57800323HCID 57800323, compound

Procedure

Synthesized as described in Example 4 using 5-bromo-2-methyl-4-(trifluoromethyl)-1H-indole and (bromomethyl)cyclopropane: 1H NMR (400 MHz, CDCl3) δ 7.38 (d, J=8.4 Hz, 1H), 7.26 (d, J=8.4 Hz, 1H), 6.49 (s, 1H), 3.99 (d, J=6.4 Hz, 2H), 2.46 (s, 3H), 1.14 (m, 1H), 0.56 (m, 2H), 0.32 (m, 2H); MS (ES) m/z 332 (M+1, isotope for Br) and 334 (M+1, isotope for Br).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-a3ba38a5fd534c3ba624700e1ff27de2
Source dataset
uspto-grants-2014_03
Patent number
US08673948B2

Reaction notes

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