6-(Trifluoromethyl)nicotinohydrazide → 2-Methyl-4-(trifluoromethyl)-1-({5-[6-(trifluoromethyl)-3-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)-1H-indole-5-carbonitrile

Participants

Role	Name	HCID	Charge
Reactant	6-(Trifluoromethyl)nicotinohydrazide	HCID 2777553	—
Reactant	[5-cyano-2-methyl-4-(trifluoromethyl)-1H-indol-1-yl]acetic acid	HCID 67404858	—
Product	2-Methyl-4-(trifluoromethyl)-1-({5-[6-(trifluoromethyl)-3-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)-1H-indole-5-carbonitrile	HCID 86620669	—

Reaction Steps

Synthesized as described in Example 35C using [5-cyano-2-methyl-4-(trifluoromethyl)-1H-indol-1-yl]acetic acid and 6-(trifluoromethyl)-3-pyridinecarbohydrazide: 1H NMR (400 MHz, DMSO-d6) δ 9.27 (s, 1H), 8.54 (d, J=8.3 Hz, 1H), 8.11 (d, J=8.3 Hz, 1H), 8.08 (d, J=8.3 Hz, 1H), 7.78 (d, J=8.3 Hz, 1H), 6.66 (s, 1H), 6.03 (s, 2H), 2.58 (s, 3H); MS (ES) m/z 474 (M+Na).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08673948B2
Source dataset	uspto-grants-2014_03
ORD ID	ord-f1df1fd275b340cc90d00c26e7b67863
Source note	uspto-grants-2014_03