Trifluoroacetic acid → 5-Bromo-4-chloro-2-(trifluoromethyl)-1H-benzimidazole

HRID 1188505Notes

Reaction equation

HRID 1188505 reaction equation
[Br:1][C:2]1[C:3]([Cl:10])=[C:4]([NH2:9])[C:5]([NH2:8])=[CH:6][CH:7]=1.[C:11](O)([C:13]([F:16])([F:15])[F:14])=O>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]2[NH:8][C:11]([C:13]([F:16])([F:15])[F:14])=[N:9][C:4]=2[C:3]=1[Cl:10]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 578001544-Bromo-3-chlorobenzene-1,2-diamine

Product 1

HCID 578003545-Bromo-4-chloro-2-(trifluoromethyl)-1H-benzimidazole

Procedure

Synthesized as described in Example 195C from 4-bromo-3-chloro-1,2-benzenediamine and TFA: MS (ESI) m/z 301 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-be3bc2a54c5349648c351a768a1b5662
Source dataset
uspto-grants-2014_03
Patent number
US08673948B2

Reaction notes

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