2,2,2-Trifluoroethyl trifluoromethanesulfonate → 4-Chloro-5-(methyloxy)-1-(2,2,2-trifluoroethyl)-2-(trifluoromethyl)-1H-benzimidazole

HRID 1188512Notes

Reaction equation

HRID 1188512 reaction equation
[Cl:1][C:2]1[C:10]2[N:9]=[C:8]([C:11]([F:14])([F:13])[F:12])[NH:7][C:6]=2[CH:5]=[CH:4][C:3]=1[O:15][CH3:16].O([CH2:25][C:26]([F:29])([F:28])[F:27])S(C(F)(F)F)(=O)=O>>[Cl:1][C:2]1[C:10]2[N:9]=[C:8]([C:11]([F:12])([F:13])[F:14])[N:7]([CH2:25][C:26]([F:29])([F:28])[F:27])[C:6]=2[CH:5]=[CH:4][C:3]=1[O:15][CH3:16]

Participants

3

Reactant 2

HCID 803662,2,2-Trifluoroethyl trifluoromethanesulfonateHCID 578002944-Chloro-5-(methyloxy)-2-(trifluoromethyl)-1H-benzimidazole

Product 1

HCID 578001464-Chloro-5-(methyloxy)-1-(2,2,2-trifluoroethyl)-2-(trifluoromethyl)-1H-benzimidazole

Procedure

Synthesized as described in Example 195D from 4-chloro-5-(methyloxy)-2-(trifluoromethyl)-1H-benzimidazole and trifluoroethyl triflate: MS (ESI) m/z 333 (M+1).

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-3e7b1a7380ea4952b5c3c13b04217e49
Source dataset
uspto-grants-2014_03
Patent number
US08673948B2

Reaction notes

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