反应详情

7-methoxyindan-1-one oxime (2.92 g, 16 mmol) was dissolved in acetic acid (150 mL) and hydrogenated on the H-Cube: 1 mL/min flow rate, 80° C., 100 bar with 10% Pd/C. The reaction mixture was evaporated, the residue was dissolved in methanol and 1 equivalent of hydrochloric acid in methanol was added. The solvent was evaporated and the residue was triturated with diethyl ether to give 7-methoxy-1-aminoindane hydrochloride (2.38 g, 12 mmol, 75%). ESMS m/z 147 (M+H)+.

1. custom1 mL/min flow rate, 80° C., 100 bar
2. customThe reaction mixture was evaporated
3. dissolutionthe residue was dissolved in methanol
4. customThe solvent was evaporated
5. customthe residue was triturated with diethyl ether