反应详情

温度

50 °C

Ethyl 7-[(1-methyl-1H-imidazol-2-yl)methoxy]-5-[4-(methylsulfonyl)phenoxy]-1H-indole-2-carboxylate (100 mg) was dissolved in a mixed solvent of tetrahydrofuran (2 mL)-ethanol (2 mL), 1M aqueous sodium hydroxide solution (2 mL) was added, and the mixture was stirred at 50° C. for 50 min. The reaction. solution was allowed to cool to room temperature, and concentrated under reduced pressure. Water was added to the residue, and the mixture was neutralized with 1M hydrochloric acid. The obtained crystals were collected by filtration, and washed successively with water and diethyl ether to give the title compound (80 mg, yield 86%) as a white solid. The white solid was recrystallized from N,N-dimethylformamide-water to give colorless crystals. melting point 209-210° C. (decomposition).

1. additionwas added
2. customThe reaction
3. temperatureto cool to room temperature
4. concentrationconcentrated under reduced pressure
5. additionWater was added to the residue
6. filtrationThe obtained crystals were collected by filtration
7. washwashed successively with water and diethyl ether