反应详情

温度

50 °C

To a solution of 7-methoxy-5-{[6-(methylsulfonyl)pyridin-3-yl]oxy}-1H-indole-2-carboxamide (0.66 g) in tetrahydrofuran (150 mL) was added Lawesson's reagent (0.89 g), and the mixture was stirred at 50° C. for 1 h. Tetrahydrofuran (100 mL) and Lawesson's reagent (0.42 g) were added to the mixture. After stirring at 50° C. for 13 h, the mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane=20/80 to 100/0, volume ratio) to give the title compound (0.68 g, 99%) as a yellow amorphous solid. MS 378 (MH+).

1. stirringAfter stirring at 50° C. for 13 h
2. concentrationthe mixture was concentrated under reduced pressure
3. customThe residue was purified by silica gel column chromatography (ethyl acetate/hexane=20/80 to 100/0, volume ratio)