反应详情

温度

50 °C

To a solution of 7-[2-methoxy-1-(methoxymethyl)ethoxy]-5-{[6-(methylsulfonyl)pyridin-3-yl]oxy}-1H-indole-2-carboxamide (1.0 g) in tetrahydrofuran (15 mL) was added Lawesson's reagent (1.0 g) and the mixture was stirred at 50° C. for 45 min. The mixture was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (ethyl acetate/hexane=10/90 to 70/30, volume ratio) to give the title compound (0.94 g, 90%) as a yellow amorphous solid. MS 466 (MH+).

1. concentrationThe mixture was concentrated under reduced pressure
2. customthe residue was purified by silica gel column chromatography (ethyl acetate/hexane=10/90 to 70/30, volume ratio)