HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → 2-[3-(Benzyloxy)-4-nitrophenoxy]-5-(methylsulfonyl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Bromo-5-(methylsulfonyl)pyridine | HCID 9899483 | — |
| Reactant | 3-(Benzyloxy)-4-nitrophenol | HCID 10977711 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-[3-(Benzyloxy)-4-nitrophenoxy]-5-(methylsulfonyl)pyridine | HCID 66885872 | 89% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of 3-(benzyloxy)-4-nitrophenol (31.4 g), 2-bromo-5-(methylsulfonyl)pyridine (30.3 g), cesium carbonate (83.6 g) and N,N-dimethylformamide (300 mL) was stirred at 100° C. for 3 h. The mixture was concentrated under reduced pressure. Water was added to the residue and the resulting brown suspension was filtered to give the title compound (45.6 g, 89%) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08673942B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-dc35f9b748814c8188e6750b951ea4fc |
| Source note | uspto-grants-2014_03 |