反应详情

温度

100 °C

A mixture of 3-(benzyloxy)-4-nitrophenol (31.4 g), 2-bromo-5-(methylsulfonyl)pyridine (30.3 g), cesium carbonate (83.6 g) and N,N-dimethylformamide (300 mL) was stirred at 100° C. for 3 h. The mixture was concentrated under reduced pressure. Water was added to the residue and the resulting brown suspension was filtered to give the title compound (45.6 g, 89%) as a yellow solid.

1. concentrationThe mixture was concentrated under reduced pressure
2. additionWater was added to the residue
3. filtrationthe resulting brown suspension was filtered