反应详情

To a solution of 2-(benzyloxy)-4-{[5-(methylsulfonyl)pyridin-2-yl]oxy}aniline (46 g) in a mixture of tetrahydrofuran (400 mL) and methanol (150 mL) was added palladium on carbon (7 g, 10 weight %, wet), and the mixture was stirred at room temperature for 15 h under hydrogen atmosphere. The mixture was filtered to remove the catalyst and the filtrate was concentrated. The residual solid was washed with methanol-diethyl ether to give the title compound (26.91 g, 84%) as a greenish-gray solid. MS 281 (MH+).

1. filtrationThe mixture was filtered
2. customto remove the catalyst
3. concentrationthe filtrate was concentrated
4. washThe residual solid was washed with methanol-diethyl ether