反应详情

温度

50 °C

In analogy to the method as described in Tetrahedron., 2000, 56, 5735-5742, a mixture of the 4-pentynoic acid (10 g, 102 mmol) and H2SO4 98% (0.338 mL, 6.12 mmol) in ethanol (113 mL) was heated at 50° C. overnight. The reaction mixture was concentrated and the crude product was dissolved in ethyl acetate, washed with NaHCO3 1M and water. The solvent was removed under reduced pressure to afford 9.04 g of ethyl pent-4-ynoate (Yield: 70%) as a colorless oil.

1. concentrationThe reaction mixture was concentrated
2. dissolutionthe crude product was dissolved in ethyl acetate
3. washwashed with NaHCO3 1M and water
4. customThe solvent was removed under reduced pressure