2-Bromopyridine → HCID 66598097, compound

HRID 1189124Notes

Reaction equation

HRID 1189124 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[CH2:8]([C:12]1[O:13][C:14]2[C:20]([OH:21])=[CH:19][CH:18]=[CH:17][C:15]=2[N:16]=1)[CH2:9][C:10]#[CH:11]>>[N:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[C:11]#[C:10][CH2:9][CH2:8][C:12]1[O:13][C:14]2[C:20]([OH:21])=[CH:19][CH:18]=[CH:17][C:15]=2[N:16]=1

Participants

3

Reactant 2

HCID 79732-BromopyridineHCID 86086808HCID 86086808, compound

Product 1

HCID 66598097HCID 66598097, compoundYield 5.5%

Procedure

The title compound was prepared in accordance with the general method of Example 1, from 2-bromopyridine (110 mg, 0.69 mol) and 2-(but-3-ynyl)benzo[d]oxazol-7-ol (130 mg, 0.69 mmol). The crude residue was purified by flash chromatography (DCM/MeOH 98:2) to yield 10 mg (38 μmol, 5%) of 2-(4-(pyridin-2-yl)but-3-ynyl)benzo[d]oxazol-7-ol.

Workup

  1. customThe crude residue was purified by flash chromatography (DCM/MeOH 98:2)

Sources & evidence

ORD record
ord-0fea4e9214f046b0a1da4fbcda527bd6
Source dataset
uspto-grants-2014_03
Patent number
US08674106B2

Reaction notes

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