Methanesulfonyl chloride → 4-(6-(Fluoromethyl)pyridin-2-yl)but-3-ynyl methanesulfonate
Reaction equation
[F:1][CH2:2][C:3]1[N:8]=[C:7]([C:9]#[C:10][CH2:11][CH2:12][OH:13])[CH:6]=[CH:5][CH:4]=1.[CH3:14][S:15](Cl)(=[O:17])=[O:16]>>[CH3:14][S:15]([O:13][CH2:12][CH2:11][C:10]#[C:9][C:7]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:2][F:1])[N:8]=1)(=[O:17])=[O:16]Participants
3
Procedure
The title compound was prepared in accordance with the general method of Example 199(B), from 4-(6-(fluoromethyl)pyridin-2-yl)but-3-yn-1-ol (2.60 g, 15 mmol) and methanesulfonyl chloride (1.50 mL, 19 mmol) to afford 2.90 g of 4-(6-(fluoromethyl)pyridin-2-yl)but-3-ynyl methanesulfonate (Yield: 78%) as a pale yellow oil which was used in the next step without further purification.
Sources & evidence
- ORD record
- ord-9a85a6525e4247d8aac71bf8e480e7be
- Source dataset
- uspto-grants-2014_03
- Patent number
- US08674106B2
Reaction notes
Loading…