Methanesulfonyl chloride → 4-(6-(Fluoromethyl)pyridin-2-yl)but-3-ynyl methanesulfonate

Participants

Reaction Steps

The title compound was prepared in accordance with the general method of Example 199(B), from 4-(6-(fluoromethyl)pyridin-2-yl)but-3-yn-1-ol (2.60 g, 15 mmol) and methanesulfonyl chloride (1.50 mL, 19 mmol) to afford 2.90 g of 4-(6-(fluoromethyl)pyridin-2-yl)but-3-ynyl methanesulfonate (Yield: 78%) as a pale yellow oil which was used in the next step without further purification.

Provenance & Evidence