Tert-Butylamine → HCID 67134197, compound

HRID 1189455Notes

Reaction equation

HRID 1189455 reaction equation
F[C:2]1[C:11]([N+:12]([O-:14])=[O:13])=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([CH2:15][O:16][CH3:17])[CH:3]=1.[C:18]([NH2:22])([CH3:21])([CH3:20])[CH3:19]>N1C=CC=CC=1>[C:18]([NH:22][C:2]1[C:11]([N+:12]([O-:14])=[O:13])=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([CH2:15][O:16][CH3:17])[CH:3]=1)([CH3:21])([CH3:20])[CH3:19]

Participants

4

Reactant 2

HCID 6385Tert-ButylamineHCID 58575197HCID 58575197, compound

Product 1

HCID 67134197HCID 67134197, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a mixed liquid of 5.50 g of methyl 4-fluoro-2-(methoxymethyl)-5-nitrobenzoate and 55.0 mL of pyridine was added 7.20 mL of tert-butylamine, followed by stirring at room temperature overnight. The solvent was evaporated under reduced pressure, and to the residue was added water. Then, 1 M hydrochloric acid was added thereto to adjust the pH to about 4, and the precipitated solid was collected by filtration and dried under reduced pressure to obtain 6.82 g of methyl 4-(tert-butylamino)-2-(methoxymethyl)-5-nitrobenzoate as a yellow solid.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. additionto the residue was added water
  3. additionThen, 1 M hydrochloric acid was added
  4. filtrationthe precipitated solid was collected by filtration
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-cc460e5a5ce349f8a9f5f0907e3d0bf7
Source dataset
uspto-grants-2014_03
Patent number
US08674096B2

Reaction notes

Loading…