反应详情

To a mixture of 106 mg of 1-(4,4-difluorocyclohexyl)-7-[(5-fluoro-2,3-dihydro-1H-indol-1-yl)carbonyl]-8-methyl[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one, 1 mL of methanol, and 1 mL of tetrahydrofuran was added 55 μL of 4 M hydrogen chloride/ethyl acetate, followed by stirring at room temperature for 1 hour. The reaction solution was concentrated under reduced pressure. The obtained residue was triturated with a mixture of ethyl acetate, diethyl ether, and normal hexane to give a powder, and the suspension was stirred for 30 minutes. The solid was collected by filtration and dried under reduced pressure to obtain 97 mg of 1-(4,4-difluorocyclohexyl)-7-[(5-fluoro-2,3-dihydro-1H-indol-1-yl)carbonyl]-8-methyl[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one hydrochloride as a pale yellow solid.

1. concentrationThe reaction solution was concentrated under reduced pressure
2. customThe obtained residue was triturated with a mixture of ethyl acetate, diethyl ether, and normal hexane
3. customto give a powder
4. stirringthe suspension was stirred for 30 minutes
5. filtrationThe solid was collected by filtration
6. customdried under reduced pressure