2-Naphthol → Benzo(b)naphtho(1,2-d)furan

HRID 1189599Notes

Reaction equation

HRID 1189599 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[OH:11]>CCOCC>[CH:9]1[C:10]2[C:1]3[C:1]4[CH:10]=[CH:5][CH:4]=[CH:3][C:2]=4[O:11][C:2]=3[CH:3]=[CH:4][C:5]=2[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 1

HCID 86632-Naphthol

Product 1

HCID 268932Benzo(b)naphtho(1,2-d)furan

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Next, the β-naphthol derivative having a halogen group (b3) is intramolecularly cyclized by formation of an ether bond according to a Williamson ether synthesis to form a benzo[b]naphtho[1,2-d]furan ring, so that a benzo[b]naphtho[1,2-d]furan compound (b4) can be obtained.

Workup

  1. customto form a benzo[b]naphtho[1,2-d]furan ring

Sources & evidence

ORD record
ord-0a338424031c44fcaceb333550a6accc
Source dataset
uspto-grants-2014_03
Patent number
US08674117B2

Reaction notes

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