反应详情

3-Amino-2,4-dichloro-benzylamine (2.28 g, 11.9 mmol) is added to a mixture of 2,2-dimethyl-propionic acid chloride (1.47 mL, 11.9 mmol) and TEA (4.14 mL, 29.8 mmol) in THF (90 mL) and it is stirred for 3 h. The reaction mixture is concentrated, diluted with EtOAc, washed with 5% aq NaHCO3 solution and water, dried with Na2SO4, filtered and concentrated to give the sub-title compound.

1. concentrationThe reaction mixture is concentrated
2. additiondiluted with EtOAc
3. washwashed with 5% aq NaHCO3 solution and water
4. dry with materialdried with Na2SO4
5. filtrationfiltered
6. concentrationconcentrated