反应详情

A mixture of 2-fluoroisobutyric acid (555 mg, 5.2 mmol), 3-amino-2,4-dichloro-benzylamine (1.00 g, 5.2 mmol), TBTU (1.85 g, 5.8 mmol), TEA (1.82 mL, 13 mmol) and THF is stirred at rt overnight. The mixture is concentrated, stirred with sat. aq NaHCO3-solution and the resulting precipitate is collected by filtration, washed with water and dried.

1. concentrationThe mixture is concentrated
2. stirringstirred with sat. aq NaHCO3-solution
3. filtrationthe resulting precipitate is collected by filtration
4. washwashed with water
5. customdried