反应详情

1,1′-Thiocarbonyldi-2-pyridone (1.21 g, 5.2 mmol) is added to a mixture of N-(3-amino-2,4-dichloro-benzyl)-2-methyl-2-fluoro-propionamide (1.32 g, 4.7 mmol) and dioxane (25 mL) and it is stirred at reflux for 2 d. The mixture is diluted with water, most of the dioxane is removed under reduced pressure and the resulting precipitate is collected by filtration, washed with water and dried.

1. temperatureat reflux for 2 d
2. customis removed under reduced pressure
3. filtrationthe resulting precipitate is collected by filtration
4. washwashed with water
5. customdried