1,1'-Thiocarbonyldi-2(1H)-pyridone → N-(2,4-Dichloro-3-isothiocyanato-benzyl)-2-methyl-2-fluoro-propionamide

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Reaction Steps

1,1′-Thiocarbonyldi-2-pyridone (1.21 g, 5.2 mmol) is added to a mixture of N-(3-amino-2,4-dichloro-benzyl)-2-methyl-2-fluoro-propionamide (1.32 g, 4.7 mmol) and dioxane (25 mL) and it is stirred at reflux for 2 d. The mixture is diluted with water, most of the dioxane is removed under reduced pressure and the resulting precipitate is collected by filtration, washed with water and dried.

Provenance & Evidence