反应详情

A mixture of 2-fluoro-4-methylamino-5-nitro-benzoic acid (0.500 g, 2.34 mmol), (1-chloro-2-methyl-propenyl)-dimethylamine (0.371 mL, 2.80 mmol) and DCM (50 mL) is stirred for 30 min, then 4-fluoro-3-chloro-aniline (0.340 g, 2.34 mmol) and DIPEA (0.549 mL, 3.15 mmol) are added and it is stirred for 2 h. The mixture is concentrated, water is added and the precipitate is filtered, washed with water and dried to give the subtitle compound.

1. stirringit is stirred for 2 h
2. concentrationThe mixture is concentrated
3. additionwater is added
4. filtrationthe precipitate is filtered
5. washwashed with water
6. customdried