HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1189637Generated: October 31, 2026
Hydrochloric Acid → 2-(4-Fluoro-piperidinyl)-4-amino-5-nitro-benzoic acid
https://huagongshe.com/reaction/1189637
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Fluoropiperidine | HCID 2759159 | — |
| Reactant | 4-Amino-2-fluoro-5-nitrobenzoic acid | HCID 59785337 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(4-Fluoro-piperidinyl)-4-amino-5-nitro-benzoic acid | HCID 67957575 | — |
Reaction Steps
A mixture of 4-fluoropiperidine×HCl (691 mg, 4.9 mmol), TEA (2.2 ml, 16 mmol), 2-fluoro-4-amino-5-nitro-benzoic acid (900 mg, 4.5 mmol) and DMF (15 mL) is stirred for 4.5 h at 50° C. Then the mixture is concentrated, diluted with water and the precipitate is filtered and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08674113B2 |
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| Source dataset | uspto-grants-2014_03 |
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| ORD ID | ord-35ee84f79cc6462dbbf0a5b683efb792 |
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| Source note | uspto-grants-2014_03 |
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