反应详情

温度

50 °C

A mixture of 4-fluoropiperidine×HCl (691 mg, 4.9 mmol), TEA (2.2 ml, 16 mmol), 2-fluoro-4-amino-5-nitro-benzoic acid (900 mg, 4.5 mmol) and DMF (15 mL) is stirred for 4.5 h at 50° C. Then the mixture is concentrated, diluted with water and the precipitate is filtered and dried.

1. concentrationThen the mixture is concentrated
2. additiondiluted with water
3. filtrationthe precipitate is filtered
4. customdried