HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 178507776, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | HCID 178507856 | HCID 178507856 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178507776 | HCID 178507776 | — |
Reaction Steps
A mixture of N-(trans-4-trifluoromethyl-cyclohexyl)-2-(4-fluoro-piperidinyl)-4-amino-5-nitro-benzoic acid amide (150 mg, 0.35 mmol), Ra—Ni (15 mg), MeOH (2 mL) and THF (10 mL) is stirred under 50 psi H2-atmosphere for 1 h. The mixture is filtered and concentrated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08674113B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-5cd13991f9ee44929cb24f4086e21a4f |
| Source note | uspto-grants-2014_03 |