Methanol → HCID 178507776, compound

HRID 1189638Notes

Reaction equation

HRID 1189638 reaction equation
[F:1][C:2]([F:30])([F:29])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:28])[C:11]2[CH:16]=[C:15]([N+:17]([O-])=O)[C:14]([NH2:20])=[CH:13][C:12]=2[N:21]2[CH2:26][CH2:25][CH:24]([F:27])[CH2:23][CH2:22]2)[CH2:5][CH2:4]1.CO>[Ni].C1COCC1>[F:29][C:2]([F:1])([F:30])[C@H:3]1[CH2:4][CH2:5][C@H:6]([NH:9][C:10](=[O:28])[C:11]2[CH:16]=[C:15]([NH2:17])[C:14]([NH2:20])=[CH:13][C:12]=2[N:21]2[CH2:26][CH2:25][CH:24]([F:27])[CH2:23][CH2:22]2)[CH2:7][CH2:8]1

Participants

5

Reactant 2

HCID 887MethanolHCID 178507856HCID 178507856, compound

Product 1

HCID 178507776HCID 178507776, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of N-(trans-4-trifluoromethyl-cyclohexyl)-2-(4-fluoro-piperidinyl)-4-amino-5-nitro-benzoic acid amide (150 mg, 0.35 mmol), Ra—Ni (15 mg), MeOH (2 mL) and THF (10 mL) is stirred under 50 psi H2-atmosphere for 1 h. The mixture is filtered and concentrated.

Workup

  1. filtrationThe mixture is filtered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-5cd13991f9ee44929cb24f4086e21a4f
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

Loading…