Tetrahydrofuran → HCID 178482233, compound

HRID 1189641Notes

Reaction equation

HRID 1189641 reaction equation
[F:1][C:2]([F:33])([F:32])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:31])[C:11]2[CH:16]=[C:15]([N+:17]([O-])=O)[C:14]([NH:20][CH3:21])=[CH:13][C:12]=2[N:22]2[CH2:26][CH2:25][CH:24]([C:27]([F:30])([F:29])[F:28])[CH2:23]2)[CH2:5][CH2:4]1.C1COCC1>[Pd].CO>[F:32][C:2]([F:1])([F:33])[C@H:3]1[CH2:4][CH2:5][C@H:6]([NH:9][C:10](=[O:31])[C:11]2[CH:16]=[C:15]([NH2:17])[C:14]([NH:20][CH3:21])=[CH:13][C:12]=2[N:22]2[CH2:26][CH2:25][CH:24]([C:27]([F:30])([F:28])[F:29])[CH2:23]2)[CH2:7][CH2:8]1

Participants

5

Reactant 2

HCID 8028TetrahydrofuranHCID 178482234HCID 178482234, compound

Product 1

HCID 178482233HCID 178482233, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of N-(trans-4-trifluoromethyl-cyclohexyl)-2-[3-trifluoromethyl-pyrrolidinyl]-4-methylamino-5-nitro-benzoic acid amide (110 mg, 0.23 mmol), Pd/C (10 mg), THF (5 mL) and MeOH (10 mL) is stirred under 3 bar H2-atmosphere for 2 d. The mixture is filtered, and the filtrate is concentrated and directly used in the next step.

Workup

  1. filtrationThe mixture is filtered
  2. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-5a9668896fc446479b37638efc857be5
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

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