Methyl-2-[3,3-difluoro-pyrrolidinyl]-4-methylamino-5-nitro-benzoate → Methyl-2-[3,3-difluoro-pyrrolidinyl]-4-methylamino-5-amino-benzoate

HRID 1189646Notes

Reaction equation

HRID 1189646 reaction equation
[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:9]=[C:8]([N+:10]([O-])=O)[C:7]([NH:13][CH3:14])=[CH:6][C:5]=1[N:15]1[CH2:19][CH2:18][C:17]([F:21])([F:20])[CH2:16]1>[Pd].CO>[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:9]=[C:8]([NH2:10])[C:7]([NH:13][CH3:14])=[CH:6][C:5]=1[N:15]1[CH2:19][CH2:18][C:17]([F:20])([F:21])[CH2:16]1

Participants

4

Reactant 1

HCID 67957632Methyl-2-[3,3-difluoro-pyrrolidinyl]-4-methylamino-5-nitro-benzoate

Product 1

HCID 67956984Methyl-2-[3,3-difluoro-pyrrolidinyl]-4-methylamino-5-amino-benzoate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of methyl-2-[3,3-difluoro-pyrrolidinyl]-4-methylamino-5-nitro-benzoate (1.32 g, 4.19 mmol), Pd/C (100 mg) and MeOH (25 mL) is stirred for 5 h under 3 bar H2-atmosphere. The mixture is filtered, and the filtrate is concentrated.

Workup

  1. filtrationThe mixture is filtered
  2. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-e3f8102df5394f27a6ac3890f85e170b
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

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