HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl-2-[3,3-difluoro-pyrrolidinyl]-4-methylamino-5-nitro-benzoate → Methyl-2-[3,3-difluoro-pyrrolidinyl]-4-methylamino-5-amino-benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl-2-[3,3-difluoro-pyrrolidinyl]-4-methylamino-5-nitro-benzoate | HCID 67957632 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl-2-[3,3-difluoro-pyrrolidinyl]-4-methylamino-5-amino-benzoate | HCID 67956984 | — |
Reaction Steps
A mixture of methyl-2-[3,3-difluoro-pyrrolidinyl]-4-methylamino-5-nitro-benzoate (1.32 g, 4.19 mmol), Pd/C (100 mg) and MeOH (25 mL) is stirred for 5 h under 3 bar H2-atmosphere. The mixture is filtered, and the filtrate is concentrated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08674113B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-e3f8102df5394f27a6ac3890f85e170b |
| Source note | uspto-grants-2014_03 |