HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 86666468, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2,2-Difluoroethanamine | HCID 136274 | — |
| Reactant | Ethyl 2,4-difluoro-5-nitrobenzoate | HCID 22330120 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 86666468 | HCID 86666468 | — |
Reaction Steps
2,2-Difluoro-ethylamine (2.4 g, 29.8 mmol) in THF is added at 0° C. to ethyl-2,4-difluoro-5-nitro-benzoate (4.6 g, 20 mmol) and it is stirred overnight at rt. Water is added to the mixture and the mixture is concentrated. The precipitate is filtered, washed with water and dried with P2O5 in vacuo. Yield: 3.8 g (66%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08674113B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-03a1b3069021427686fe0be340196323 |
| Source note | uspto-grants-2014_03 |