Water → HCID 86666468, compound

HRID 1189656Notes

Reaction equation

HRID 1189656 reaction equation
[F:1][CH:2]([F:5])[CH2:3][NH2:4].[CH2:6]([O:8][C:9](=[O:21])[C:10]1[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[C:13](F)=[CH:12][C:11]=1[F:20])[CH3:7].O>C1COCC1>[CH2:6]([O:8][C:9](=[O:21])[C:10]1[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[C:13]([NH:4][CH2:3][CH:2]([F:5])[F:1])=[CH:12][C:11]=1[F:20])[CH3:7]

Participants

5

Reactant 3

HCID 962WaterHCID 1362742,2-DifluoroethanamineHCID 22330120Ethyl 2,4-difluoro-5-nitrobenzoate

Product 1

HCID 86666468HCID 86666468, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2,2-Difluoro-ethylamine (2.4 g, 29.8 mmol) in THF is added at 0° C. to ethyl-2,4-difluoro-5-nitro-benzoate (4.6 g, 20 mmol) and it is stirred overnight at rt. Water is added to the mixture and the mixture is concentrated. The precipitate is filtered, washed with water and dried with P2O5 in vacuo. Yield: 3.8 g (66%).

Workup

  1. concentrationthe mixture is concentrated
  2. filtrationThe precipitate is filtered
  3. washwashed with water
  4. dry with materialdried with P2O5 in vacuo

Sources & evidence

ORD record
ord-03a1b3069021427686fe0be340196323
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

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