Diisopropylethylamine → HCID 86666470, compound

HRID 1189658Notes

Reaction equation

HRID 1189658 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]([NH:11][CH2:12][CH:13]([F:15])[F:14])[C:8]([N+:16]([O-:18])=[O:17])=[CH:7][C:3]=1[C:4]([OH:6])=O.[F:19][C:20]([F:30])([F:29])[O:21][C:22]1[CH:28]=[CH:27][C:25]([NH2:26])=[CH:24][CH:23]=1.ClC(N(C)C)=C(C)C.CCN(C(C)C)C(C)C>C(Cl)Cl>[F:19][C:20]([F:29])([F:30])[O:21][C:22]1[CH:23]=[CH:24][C:25]([NH:26][C:4](=[O:6])[C:3]2[CH:7]=[C:8]([N+:16]([O-:18])=[O:17])[C:9]([NH:11][CH2:12][CH:13]([F:15])[F:14])=[CH:10][C:2]=2[Cl:1])=[CH:27][CH:28]=1

Participants

6

Reactant 4

HCID 81531DiisopropylethylamineHCID 6008484-(Trifluoromethoxy)anilineHCID 6407921-Chloro-N,N-2-trimethylpropenylamineHCID 86666469HCID 86666469, compound

Product 1

HCID 86666470HCID 86666470, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The sub-title compound is prepared in analogy to 1b from 2-chloro-4-(2,2-difluoro-ethylamino)-5-nitro-benzoic acid (2.00 g, 7.1 mmol), 4-trifluoromethoxyaniline (0.96 mL, 7.1 mmol), (1-chloro-2-methyl-propenyl)-dimethylamine (1.13 mL, 8.5 mmol), DIPEA (2.85 mL, 16 mmol) and DCM (40 mL).

Sources & evidence

ORD record
ord-27c098e5f30e4b66b19b111a9d8a192d
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

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